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Use of liposome in treatment of diseases

Use of liposome in treatment of diseases

Liposomes are acceptable and superior carriers and have ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Due to new developments in liposome technology, several liposome-based drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their bio-distribution. This review discusses the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use, their preparation method, targeting, mechanism of formation, liposome component and the problems associated with further exploitation of this drug delivery system.

Liposomes are concentric bilayered vesicle in which an aqueous volume is entirely enclosed by a membranous lipid bilayer mainly composed of natural or synthetic phospholipids.

Liposome carriers, well known for their potential application. Liposomes are acceptable and superior carriers and have ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. There are a number of methods available by which liposomes can be manufactured separately depending on the property of molecule. The liposomes containing drugs can be administrated by many routes (intravenous, oral inhalation, local application, ocular) and these can be used for the treatment of various diseases.

Use of liposome in treatment of diseases Use of liposome in treatment of diseases Reviewed by Ankit Karma on April 28, 2016 Rating: 5

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